Developmentally arrested structures preceding cerebellar tumors in von Hippel–Lindau disease
نویسندگان
چکیده
منابع مشابه
Arrested Cerebellar Development: a Type of Cerebellar Degeneration in Amaurotic Idiocy.
This paper reports on four cases of a specific type of cerebellar degeneration which suggests an arrest of cerebellar development at an early foetal stage. Histochemical and silver stain studies were necessary to demonstrate some of the more characteristic features which strikingly distinguished this type of degeneration from the granular layer type of cerebellar degeneration or the common type...
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von Hippel-Lindau disease (VHL) patients develop highly vascular tumors, including central nervous system hemangioblastomas. It has been hypothesized that the vascular nature of these tumors is the product of reactive angiogenesis. However, recent data indicate that VHL-associated hemangioblastoma neoplastic cells originate from embryologically-arrested hemangioblasts capable of blood and endot...
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CONTEXT Endolymphatic sac tumors (ELSTs) are associated with von Hippel-Lindau disease and cause irreversible sensorineural hearing loss (SNHL) and vestibulopathy. The underlying mechanisms of audiovestibular morbidity remain unclear and optimal timing of treatment is not known. OBJECTIVE To define the mechanisms underlying audiovestibular pathophysiology associated with ELSTs. DESIGN, SETT...
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Abstract Background: Cerebellar tumors are considered as clinically significant intracranial neoplasms and acknowledgment of their epidemiological characteristics tends to be essential. The present study was conducted in order to determine the prevalence and types of their cerebellar tumors in Shohada-e-Tajrish Hospital between 2006-2014. Materials and Methods: In the current observational...
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Although vertebrate embryogenesis is typically a continuous and dynamic process, some embryos have evolved mechanisms to developmentally arrest. The embryos of Austrofundulus limnaeus, a killifish that resides in ephemeral ponds, routinely enter diapause II (DII), a reversible developmental arrest promoted by endogenous cues rather than environmental stress. DII, which starts at 24-26 days post...
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ژورنال
عنوان ژورنال: Modern Pathology
سال: 2011
ISSN: 0893-3952,1530-0285
DOI: 10.1038/modpathol.2011.61